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Characteristics
Morphology
Enveloped, positive-sense, single-stranded RNA virus
Disease
Highly contagious intestinal disease worldwide in dogs
Zoonosis
Yes, but unknown transmission routes
Health Hazards
Host Range
Dogs
Modes of Transmission
Unknown transmission route from dogs to humans. Very few human cases identified.
Signs and Symptoms
Mild cold to no symptoms in humans.
Infectious Dose
Unknown
Incubation Period
Unknown
Medical Precautions/Treatment
Prophylaxis
None available for humans
Vaccines
None available for humans  
Treatment
None
Surveillance
Coronavirus infections are not usually diagnosed due to the mild, self-limited nature of the disease. Research laboratories have used isolation methods, electron microscopy, serology and PCR-based assays to diagnosis coronavirus infections for surveillance studies
MSU Requirements
Report any exposures
Laboratory Hazards
Laboratory Acquired Infections (LAIs)
None known
Sources
Cultures, frozen stocks, other samples described in IBC protocol.
Supplemental References
Canadian MSDS:
http://www.phac-aspc.gc.ca/lab-bio/res/psds-ftss/index-eng.php
BMBL
https://www.cdc.gov/labs/BMBL.html 
NIH Guidelines
https://osp.od.nih.gov/wp-content/uploads/NIH_Guidelines.pdf
Table Caption
Risk Group 2

Agents that are associated with human disease which is rarely serious and for which preventive or therapeutic interventions are often available.
BSL2
For all procedures involving suspected or known infectious specimen or cultures.
ABSL2
For all procedures utilizing infected animals.
Spill Procedures
Small
Notify others working in the lab. Remove PPE and don new PPE. Cover area of the spill with absorbent material and add fresh 1:10 bleach:water. Allow 20 munutes (or as directed) of contact time. After 20 minutes, cleanup and dispose of materials.
Large
  • Immediately notify all personnel in the lab and clear all personnel from the area. Remove any contaminated PPE/clothing and leave the lab. 
  • Secure the area by locking doors, posting signage and guarding the area to keep people out of the space. 
For assistance, contact MSU's Biosafety Officer (406-994-6733) or Safety and Risk Management (406-994-2711).
Exposure Procedures
Mucous membrane
Flush eyes, mouth, or nose for 5 minutes at eyewash station.
Other Exposures
Wash area with soap and water for 5 minutes.
Reporting
Immediately report incident to supervisor, complete a First Report of Injury form, and submit to Safety and Risk Management.
Medical Follow-up
During business hours: Bridger Occupational Health 3406 Laramie Drive. Weekdays 8am -6pm.  Weekends 9am-5pm
After business hours: Bozeman Deaconess Hospital Emergency Room 915 Highland Blvd Bozeman, MT
Viability
Disinfection
1:10 dilution of bleach:water, 70% ethanol, accelerated hydrogen peroxide, MicroChem
Inactivation
Inactivated by moist heat (15 minutes at 121°C)
Survival Outside Host
Unknown
Personal Protective Equipment (PPE)
Minimum PPE Requirements
Lab coat, disposable gloves, safety glasses, closed toed shoes, long pants
Additional Precautions
 Additioanl PPE may be required depending on lab specific SOPs and IBC Protocol.